On 12 September 1996 Clapton played a party for Armani at New York City's Lexington Armory with Greg Phillinganes, Nathan East and Steve Gadd. Sheryl Crow appeared on one number, performing "Tearing Us Apart", a track from August, which was first performed by Tina Turner during the Prince's Trust All-Star Rock show in 1986. It was Clapton's sole US appearance that year, following the open-air concert held at Hyde Park. The concert was taped and the footage was released both on VHS video cassette and later, on DVD.
Clapton was featured in the movie version of Tommy, the first full length rock opera, written by the Who. The movie version gave Clapton a cameo appearance as the Preacher, performing Sonny Boy Williamson's song, "Eyesight to the Blind". He appeared in Blues Brothers 2000 as one of the Louisiana Gator Boys. In addition to being in the band, he had a small speaking role. Clapton has appeared in an advertisement for the Mercedes-Benz G-Wagen. In March 2007 Clapton appeared in an advertisement for RealNetwork's Rhapsody online music service. In 2010 Clapton started appearing as a spokesman for T-Mobile, advertising their MyTouch Fender cell phone. Clapton also appeared in the 2011 BBC documentary Reggae Got Soul: The Story of Toots and the Maytals which was described as "The untold story of one of the most influential artists ever to come out of Jamaica."
When asked to describe God by their minister, the characters Eric Forman and Steven Hyde both drew an image of Clapton in the episode "Holy Crap!" of season two of That '70s Show. Clapton appeared on the BBC's Top Gear in 2013, during Series 19 Episode 4 and was involved in testing the new Kia Cee'd. He was called upon to test the Cee'd's auxiliary input, which he tested by plugging in one of his guitars and playing several bars of his most famous hits. He was introduced by Top Gear host Jeremy Clarkson as a "local guitarist".